文章基本信息

标题：Increase of Caspase-3 Activity by Lignans from Machilus thunbergii in HL-60 Cells
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作者：Bo-Young Park ; Byung-Sun Min ; Ok-Kyoung Kwon 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：8
页码：1305-1307
DOI：10.1248/bpb.27.1305
出版社：The Pharmaceutical Society of Japan
摘要：Nine lignans and two butanolides were isolated from the stem bark of Machilus thunbergii and their structures were identified as machilin A (1), licarin B (2), zuonin B (3), macelignan (4), secoisolancifolide (5), isolancifolide (6), oleiferin C (7), meso -dihydroguaiaretic acid (8), licarin A (9), machilin F (10), and nectandrin B (11) by spectroscopic means. These compounds were assessed for their abilities to activate a caspase-3 activity in human promyeloid leukemic HL-60 cells. The intracellular caspase-3 activity of macelignan (4), oleiferin C (7), meso -dihydroguaiaretic acid (8), and licarin A (9) increased approximately 3.04, 6.16, 2.10, and 3.10-fold at 100 μ M over that of untreated control. In addition, compounds 4, 7, 8, and 9 induced internucleosomal DNA fragmentation in HL-60 cells.
关键词：Machilus thunbergii;lignan;caspase-3;DNA fragmentation;apoptosis