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  • 标题:Modulation of Corydalis tuber on Glycine-Induced Ion Current in Acutely Dissociated Rat Periaqueductal Gray Neurons
  • 本地全文:下载
  • 作者:Byung-Shik Cheong ; Do-Young Choi ; Nam-Hun Cho
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2004
  • 卷号:27
  • 期号:8
  • 页码:1207-1211
  • DOI:10.1248/bpb.27.1207
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Traditionally, Corydalis tuber has been used for the control of pain including headache, stomachache, and neuralgia. In the present study, modulation of the Corydalis tuber on glycine-activated ion current in the acutely dissociated periaqueductal gray (PAG) neurons was studied by a nystatin-perforated patch-clamp technique. High concentrations of Corydalis tuber elicited ion current, which was suppressed by strychnine application, while low concentrations of Corydalis tuber reduced glycine-induced ion current in the PAG neurons. Inhibitory action of Corydalis tuber on glycine-activated ion current was partially abolished by treatment with naltrexone, a non-selective opioid antagonist. Application of N -methylmalemide (NEM), a sulfhydryl alkylating agent, also partially abolished the inhibitory action of Corydalis tuber on glycine-activated ion current in the PAG neurons. These results suggest that the inhibitory effect of Corydalis tuber on glycine-activated ion current in the PAG neurons is one of the analgesic mechanisms of the Corydalis tuber .
  • 关键词:Corydalis tuber;glycine;periaqueductal gray neurons;opioid;GTP-binding protein
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