文章基本信息

标题：The Entering of Indium-111 and Iron-59 into the Hepatocytes from Partially Hepatectomized Rats Differ from That of Gallium-67
本地全文：下载
作者：Ryota Sato ; Shinya Abe ; Yuji Yamada 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：8
页码：1193-1196
DOI：10.1248/bpb.27.1193
出版社：The Pharmaceutical Society of Japan
摘要：We recently suggested that the transferrin (Tf)–gallium-67 (⁶⁷Ga) complex dissociated on the surface of the hepatocytes after partial hepatectomy and free ⁶⁷Ga bound to heparan sulfate in the extracellular matrix. In the present study, we investigated whether the entering of indium-111 (¹¹¹In) and iron-59 (⁵⁹Fe) with high affinity to transferrin differed from the entering of ⁶⁷Ga by the hepatocytes after partial hepatectomy. ¹¹¹In was almost taken by the plasma and little taken by the red blood cell. On the other hand, the uptake of ⁵⁹Fe by the red blood cell was higher than plasma. The uptake of ⁵⁹Fe by the bone marrow was significantly higher than that of ¹¹¹In. The uptake of ¹¹¹In and ⁵⁹Fe by the liver tissue was reached a maximum 2 d after partial hepatectomy but the uptake ratio of ¹¹¹In was lower than that of ⁵⁹Fe. We suspected that the uptake of ⁵⁹Fe by the liver tissue was the highest because of the high binding affinity of Tf–⁵⁹Fe to Tf-receptor. The entering of ¹¹¹In and ⁵⁹Fe into the hepatocytes was also reached a maximum 2 d after partial hepatectomy but the ratio of ⁵⁹Fe was slightly lower than that of ¹¹¹In. These results suggested that the binding affinity to Tf could have played a crucial role in the differences of the entering of ¹¹¹In, ⁵⁹Fe and ⁶⁷Ga into the hepatocytes of partially hepatectomized rats.
关键词：indium-111 (111In);iron-59 (59Fe);partial hepatectomy;liver tissue;hepatocyte