文章基本信息

标题：Cellular Function of Calcium-Independent Phospholipase A2
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作者：Satoshi Akiba ; Takashi Sato
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：8
页码：1174-1178
DOI：10.1248/bpb.27.1174
出版社：The Pharmaceutical Society of Japan
摘要：The catalytic activity of calcium-independent phospholipase A₂ (iPLA₂), which is classified as a group VI PLA₂, is regulated by protein kinase C, calmodulin, and others such as reactive oxygen species. Numerous findings have shown that iPLA₂ is involved in stimulus-induced arachidonic acid release and lysophospholipid generation, although the participation is dependent upon the cell type and stimulus. The catalytic action of iPLA₂ is known to be responsible for phospholipid remodeling as a housekeeping function. However, it has been widely accepted that arachidonic acid and lysophospholipid generated by iPLA₂ act as a signaling molecule in cellular functions. Those include eicosanoid production, glucose-induced insulin secretion, Fas-induced apoptosis, cellular proliferation, membrane traffic in fusion, contribution to myocardial ischemia, and others. In this review, the functional role of iPLA₂ in cellular responses upon stimulation is the focus.
关键词：calcium-independent phospholipase A2;arachidonic acid;lysophospholipid;bromoenol lactone;group VI phospholipase A2