文章基本信息

标题：Tissue Distribution after Intravenous Dosing of Micafungin, an Antifungal Drug, to Rats
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作者：Toshiro Niwa ; Yoshiko Yokota ; Akira Tokunaga 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：7
页码：1154-1156
DOI：10.1248/bpb.27.1154
出版社：The Pharmaceutical Society of Japan
摘要：The tissue distribution after an intravenous dose of micafungin (1 mg/kg), a new echinocandin-like lipopeptide antifungal agent, to male rats was investigated. Micafungin in plasma disappeared biexponentially with a terminal half-life of 5.03 h. Micafungin concentrations in liver, kidney, and lung at the first sampling time (5 min) after dosing were 1.15, 1.64, and 2.58-fold higher than the plasma concentration, and the AUC _0—∞ were 1.61, 3.42, and 2.89-fold higher than that for plasma. The terminal half-lives for these tissues were 5.14, 4.87, and 5.31 h, respectively, which were comparable to those for plasma. These results suggest that micafungin distributes rapidly and moderately into tissues such as the liver, kidney, and lungs, and that the concentrations in tissues decreased in parallel with the unchanged drug in plasma.
关键词：micafungin;antifungal drug;tissue distribution;rat;pharmacokinetics