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标题：Mycelial Extract of Cordyceps ophioglossoides Prevents Neuronal Cell Death and Ameliorates β-Amyloid Peptide-Induced Memory Deficits in Rats
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作者：Da-Qing Jin ; Byung-Chul Park ; Jae-Seong Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：7
页码：1126-1129
DOI：10.1248/bpb.27.1126
出版社：The Pharmaceutical Society of Japan
摘要：Ameliorating effects of methanol extracts of Basidiomycetes against in vitro and in vivo model of Alzheimer's disease were investigated. The extracts of Cordyceps ophioglossoides and Hypocrea citrina var. citrina prevented the β-amyloid_(25—35) (Aβ_(25—35))-induced cell death in SK-N-SH neuronal cells. However, in rat model of Alzheimer's disease, 30-d intraperitoneal administration with only the extract of Cordyceps ophioglossoides significantly prevented spatial memory loss by intracranial injection of Aβ_(25—35), which was assessed in water maze task. Interestingly, the scavenging activity of the reactive oxygen species (ROS) generated in Aβ_(25—35)-treated cells was also found in the extract of Cordyceps ophioglossoides , but not in the extract of Hypocrea citrina var. citrina . These results suggest that the extract of Cordyceps ophioglossoides may protect the Aβ-induced neuronal cell death and memory loss through free radical scavenging activity. These results further suggest that Cordyceps ophioglossoides mycelium may be valuable for the protection from Alzheimer's dementia.
关键词：Cordyceps ophioglossoides;β-amyloid peptide;neuronal death;Alzheimer's dementia