文章基本信息

标题：PAP 9704, a Korean Herbal Medicine Attenuates Methamphetamine-Induced Hyperlocomotion via Adenosine A2A Receptor Stimulation in Mice
本地全文：下载
作者：Yong Soo Kwon ; Toshitaka Nabeshima ; Eun-Joo Shin 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：6
页码：906-909
DOI：10.1248/bpb.27.906
出版社：The Pharmaceutical Society of Japan
摘要：The effect of PAP 9704, a traditional prescription in Korea consisting of Polygala tenuifolia , Acorus gramineus , and Poria cocos at a ratio of 1 : 1 : 1 (dry weight), on methamphetamine (MA)-induced hyperlocomotion was examined in mice. The increased locomotor activity induced by MA (1 mg/kg/d, i.p.×7) was significantly attenuated by co-administration with PAP 9704 (100 or 200 mg/kg/d, p.o. ×7) in a dose dependent manner. Consistently, it was found that the hyperlocomotor activity occurred in parallel with the expression of striatal fos-related antigen immunoreactivity. The adenosine A_2A receptor antagonist, 1,3,7-trimethyl-8-(3-chlorostyryl)xanthine (0.5 or 1.0 mg/kg, i.p.), significantly reversed the pharmacological action of PAP 9704 in a dose related manner, but the adenosine A₁ receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine (0.5 or 1.0 mg/kg, i.p.) and the A_2B receptor antagonist alloxazine (1.5 or 3.0 mg/kg, i.p.) did not significantly affect this pharmacological action. Our results suggest that PAP 9704 prevents MA-induced hyperlocomotion, at least in part, via the stimulation of the adenosine A_2A receptor.
关键词：PAP 9704;methamphetamine;locomotor activity;adnosine A2A receptor;striatum;fos-related antigen immunoreactivity