文章基本信息

标题：Biological Activity of α-Thujaplicin, the Isomer of Hinokitiol
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作者：Yasuhiro Morita ; Eiko Matsumura ; Toshihiro Okabe 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：6
页码：899-902
DOI：10.1248/bpb.27.899
出版社：The Pharmaceutical Society of Japan
摘要：α-Thujaplicin, a minor component of Aomori Hiba ( Thujopsis dolabrata S IEB . et Z UCC . var. hondai M AKINO ), showed rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their minimum inhibitory concentrations (MICs) being in the range of 12.0—50.0 μg/ml. α-Thujaplicin and hinokitiol (the major component of Aomori Hiba) also showed clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 6.25—50 μg/ml. This compound showed strong insecticidal activity against Reticulitermes speratus [50%-lethal concentration (LC₅₀): 0.02 g/m²], and it also had clear acaricidal activity against Dermatophagoides farinae (LC₅₀: 0.66 g/m²). At 24 h after treatment, α-thujaplicin at 0.63 μg/ml inhibited the cell growth of murine P388 lymphocytic leukemia by 78%, and its cytotoxic activity at a concentration higher than 0.63 μg/ml was as high as that of vincristine, used as a positive control. On the other hand, the cytotoxic effect of α-thujaplicin at 0.63 μg/ml was weaker than that of vinblastine. In this respect, the strong cytotoxic effect of α-thujaplicin on murine P388 lymphocytic leukemia cell line should be emphasized, considering that it has recently been found to be low in toxicity to mice.
关键词：α-thujaplicin;antifungal activity;Legionella species;insecticidal activity;acaricidal activity;cytotoxic activity