文章基本信息

标题：A Citrus Flavonoid Hesperidin Suppresses Infection-Induced Endotoxin Shock in Mice
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作者：Kiichiro Kawaguchi ; Sei-ichi Kikuchi ; Ryoichi Hasunuma 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：5
页码：679-683
DOI：10.1248/bpb.27.679
出版社：The Pharmaceutical Society of Japan
摘要：Administration of a citrus flavonoid hesperidin (HES) to mice before LPS challenge significantly reduced tumor necrosis factor (TNF)-α production in a dose-dependent manner. Treatment of HES 3 h before intraperitoneal (i.p.) infection with 10⁸ CFU Salmonella typhimurium aroA resulted in rescue from lethal shock as similar to LPS-nonresponder mice. Not only bacterial numbers in livers and spleens but also plasma LPS levels significantly decreased by pretreatment with HES. In addition, HES markedly suppressed plasma levels of TNF-α and high mobility group box chromosomal protein 1 (HMGB-1), decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection. Pretreatment of LPS with HES suppressed the chromogenic Limulus reaction.
关键词：Salmonella-infection;endotoxin shock;flavonoid;hesperidin;blood coagulation factor;Limulus reaction