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标题：Role of Polymorphonuclear Leukocytes in the Resistance of Tumor-Bearing Mice against Candida albicans Infection
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作者：Yoshio Okawa ; Makiko Kobayashi ; Kazuhiko Sakai 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：5
页码：674-678
DOI：10.1248/bpb.27.674
出版社：The Pharmaceutical Society of Japan
摘要：Tumor-bearing mice showed a significant resistance against Candida albicans intravenous infection. Longer survival was observed in groups of mice inoculated with fungal cells 2—3 weeks after tumor transplantation with allogeneic sarcoma 180, syngeneic methylcholanthrene-induced Meth A fibrosarcoma, and MM 46 mammary carcinoma than in non-tumor-bearing mice inoculated only with fungal cells. This effect was not observed when the mice were infected only 1 week after tumor transplantation. A significant decrease in the number of C. albicans cells in the kidneys was observed in mice inoculated with fungal cells 2—3 weeks after tumor transplantation. In the tumor-bearing mice treated with cyclophosphamide (CY), a remarkable decrease in both the number of peripheral blood polymorphonuclear leukocytes (PMNs) and the defense against challenge with C. albicans cells was observed, as compared with the CY-untreated groups (normal and tumor-bearing mice). A marked increase in the calcium concentration in serum and number, candidacidal activity, active oxygen level, and myeloperoxidase activity of PMNs was observed in the 2—3-week tumor-bearing mice. From these results, it is suggested that PMNs, which accumulated in the 2—3-week tumor-bearing mice, play an important role in the protection from C. albicans infection by increasing the number and the types of killing factors.
关键词：tumor-bearing mouse;Candida albicans;protection against infection;polymorphonuclear leukocyte;killing factor