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标题：Danthron Inhibits the Neurotoxicity Induced by Various Compounds Causing Oxidative Damages Including β-Amyloid (25—35) in Primary Cortical Cultures
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作者：Yong-Soo Kwon ; Jae-Young Koh ; Dong-Keun Song 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：5
页码：723-726
DOI：10.1248/bpb.27.723
出版社：The Pharmaceutical Society of Japan
摘要：Oxidative stress caused by an elevation in reactive oxygen species (ROS) plays an important role in Alzheimer's disease and other neurodegenerative diseases. In this study, we examined the neuroprotective effect of danthron (1,8-dihydroxyanthraquinone) against neurotoxicities induced by β-amyloid (25—35), excitotoxins, apoptosis, and oxidative stress in primary cortical cultures. Danthron dose-dependently reduced neuronal injury induced by 30 μ M β-amyloid (25—35). Danthron significantly inhibited oxidative injury induced by 100 μ M Fe³⁺ and decreased membrane lipid peroxidation induced by 100 μ M Fe³⁺ as measured by thiobarbituric-acid-reactive substance (TBARS). Danthron (0.5—50 μ M ) ameliorated the effects of buthionine sulfoximine (BSO, 1 m M ), which depletes endogenous glutathione by 10—73%. Danthron also dose-dependently inhibited neuronal injury mediated by nitric oxide (NO) radicals, but failed to inhibit injury due to superoxide radicals (O²⁻). These results suggest danthron treatment may, in part, reduce neurotoxicity related to β-amyloid protein by both dominant inhibitory effects on membrane lipid peroxidation and glutathione deprivation.
关键词：danthron;β-amyloid protein;glutathione deprivation;lipid peroxidation;cortical culture