文章基本信息

标题：Properties of an Alginate Gel Bead Containing a Chitosan-Drug Salt
本地全文：下载
作者：Yoshifumi Murata ; Daijirou Hirai ; Kyoko Kofuji 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：3
页码：440-442
DOI：10.1248/bpb.27.440
出版社：The Pharmaceutical Society of Japan
摘要：A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solution, while releasing CMP and taking up bile acid. The amount of bile acid taken up into the Alg-CS increased incrementally according to the degree of deacetylation of CS. Furthermore, the molecular weight of CS also affected the properties of the Alg-CS. An approximately linear relationship was observed between CMP release and bile acid uptake of Alg-CS.
关键词：chitosan;drug release;bile acid adsorption;alginate gel bead