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标题：Potentiation of Cytotoxic Activity in Naïve and Tumor-Bearing Mice by Oral Administration of Hot-Water Extracts from Agaricus brazei Fruiting Bodies
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作者：Hiroaki Takimoto ; Daiko Wakita ; Kiichiro Kawaguchi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：3
页码：404-406
DOI：10.1248/bpb.27.404
出版社：The Pharmaceutical Society of Japan
摘要：When hot-water extracts of mushroom Agaricus brazei M URRILL fruiting bodies (Agaricus extracts) were administered orally into Meth A-bearing mice, tumor growth was significantly inhibited compared with controls given water orally. Treatment with Agaricus extracts for five successive days significantly increased natural killer activity of spleen cells in naïve BALB/c mice. In Meth A-bearing BALB/c mice, Agaricus extracts enhanced the induction of antigen-specific cytotoxic T lymphocytes and interferon γ production, indicating that Agaricus extracts potentiate cytotoxic activity in innate and adaptive immunity.
关键词：Agaricus blazei;Meth A;anti-tumor;natural killer (NK);cytotoxic T lymphocyte (CTL);interferon (IFN)-γ