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标题：Relationship between Liver Injury and Transglutaminase Activities in Guinea Pigs and Rats
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作者：Naoko Sato ; Shinya Abe ; Takehito Yamada 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：2
页码：236-238
DOI：10.1248/bpb.27.236
出版社：The Pharmaceutical Society of Japan
摘要：We investigated the effect of transglutaminase (TGase) on in guinea pigs and rats. Serum alanine aminotransferase (ALT) level increased 1 d after CCl₄ treatment of both in guinea pigs and rats since TGaese activity was greatly higher in guinea pigs than rats. However, serum ALT level in guinea pigs was very much lower than that in rats. Liver TGase activities decreased after CCl₄ treatment in both guinea pigs and rats. However, TGase activities in the liver from guinea pigs were higher than that from rats. Decreased TGase activities by CCl₄ in the liver from guinea pigs and rats were significantly recovered by retinoic acid treatment that was reported to increase TGase. Degree of recovery of serum ALT level by retinoic acid in rats was larger than in guinea pigs. These results suggested that the distinction of the effect of retinoic acid on serum ALT level in CCl₄-treated animals was due to the different TGase activity that increased membrane stability.
关键词：carbon tetrachloride (CCl4);transglutaminase (TGase);retinoic acid;guinea pig;rat