文章基本信息

标题：Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative
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作者：Yaowared Sumanont ; Yukihisa Murakami ; Michihisa Tohda 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：2
页码：170-173
DOI：10.1248/bpb.27.170
出版社：The Pharmaceutical Society of Japan
摘要：Curcumin manganese complex (CpCpx) and diacetylcurcumin manganese complex (AcylCpCpx) were determined as to their effect on the nitric oxide (NO) radical scavenging in vitro method using a sodium nitroprusside generating NO system compared with their parent compound and astaxanthin, an extreme antioxidant. All compounds effectively reduced the generation of NO radicals in a dose dependent manner. They exhibited strong NO radical scavenging activity with low IC₅₀ values. The IC₅₀ values of curcumin, diacetylcurcumin, CpCpx and AcylCpCpx obtained are 20.39±4.10 μ M , 28.76±1.48 μ M , 9.79±1.50 μ M and 8.09±0.99 μ M , respectively. CpCpx and AcylCpCpx show greater NO radical scavenging than their parent compounds, curcumin and acetylcurcumin, respectively. However, the IC₅₀ values of curcumin and related compounds were found to be less than astaxanthin, an extreme antioxidant, with the lower IC₅₀ value of 3.42±0.50 μ M .
关键词：curcumin;diacetylcurcumin;nitric oxide;manganese complex