文章基本信息

标题：Expression Changes of the mRNA of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain
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作者：Michihisa Tohda ; Prawpan Suwanakitch ; Rattima Jeenapongsa 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：12
页码：2021-2023
DOI：10.1248/bpb.27.2021
出版社：The Pharmaceutical Society of Japan
摘要：The rat with permanent occlusion of the bilateral common carotid arteries (2VO) is useful model for the study of dementia. The expression changes of amyloid precursor protein (APP), secretase, α7 nicotinic acetylcholine receptor (α7NicR) and acetylcholine esterase (AChE), which are involved in Alzheimer's disease, were examined by quantitative RT/PCR in this model rat brain. The expression of APP, α7NicR and secretase were increased 4 d after 2VO. The α7NicR level at 2 d after operation already tended to increase. These result suggest that α7NicR expression was enhanced at early stage of brain ischemia. Using this model to find drugs which regulate the α7NicR expression will be useful to assay the materials with anti-dementive effect.
关键词：dementia;nicotinic α7 receptor;Alzheimer's disease;model rat;gene expression