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标题：Uptake of Gallium-67 by the Hepatocytes during Liver Regeneration in Carbon Tetrachloride-Treated Mice
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作者：Shinya Abe ; Satoko Suyama ; Hitomi Shishido 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：12
页码：1913-1915
DOI：10.1248/bpb.27.1913
出版社：The Pharmaceutical Society of Japan
摘要：Gallium-67 (⁶⁷Ga) has been used as a tumor or inflammation-imaging agent in nuclear medicine. We recently reported that the peak of serum alanine aminotransferase (ALT) level was 1 d after carbon tetrachloride (CCl₄) treatment in rats. However, the peak of ⁶⁷Ga uptake by the liver tissue and hepatocytes was 2 d after the treatment. If ⁶⁷Ga is taken in the hepatic disorder phase, the pattern of ⁶⁷Ga uptake by the hepatocytes should be consistent with that of the ALT level. In order to answer why it was not, we carried out a detailed examination. The lipid peroxidation of hepatocytes from CCl₄-treated mice was greatly increased 1 d after CCl₄ treatment; serum ALT was also increased 1 d after the treatment. The uptake of ⁶⁷Ga by the liver tissue reached a maximum 1 and 2 d after the treatment, while maximum by the hepatocytes was achieved after 2 d. The incorporation of bromodeoxyuridine into the hepatocytes also reached maximum 2 d after the treatment. These results suggest that the uptake of ⁶⁷Ga by the hepatocytes is carried out during liver regeneration rather than during hepatic disorder by CCl₄ treatment.
关键词：Gallium-67 (67Ga);carbon tetrachloride (CCl4);liver tissue;hepatocyte;lipid peroxidation;bromodeoxyuridine (BrdU)