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标题：Anti-complementary Activity of Triterpenoides from Fruits of Zizyphus jujuba
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作者：Sang-Myung Lee ; Jin-Gyu Park ; You-Hee Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：11
页码：1883-1886
DOI：10.1248/bpb.27.1883
出版社：The Pharmaceutical Society of Japan
摘要：In order to determine on the anti-complement activity of triterpenes, following eleven triterpenoides were isolated from the fruits of the Zizyphus jujuba M ILL : ceanothane-type triterpenes: colubrinic acid (1), zizyberenalic acid (11); lupane-type triterpenes: alphitolic acid (2), 3- O - cis - p -coumaroyl alphitolic acid (3), 3- O - trans - p -coumaroyl alphitolic acid (4), betulinic acid (7), betulonic acid (9); and oleanane-type triterpenes: 3- O - cis - p -coumaroyl maslinic acid (5), 3- O - trans - p -coumaroyl maslinic acid (6), oleanolic acid (8), oleanonic acid (10). These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Among them, compounds 5, 6, and 8 exhibited significant anti-complement activity with IC₅₀ values of 101.4, 143.9, and 163.4 μ M , respectively, whereas the ceanothane-type and the lupane-type triterpenes were inactive. This suggests that the oleanane-structure plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.
关键词：anti-complementary activity;Zizyphus jujuba;oleanane-type triterpene;coumaroyl group