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标题：Strong Antihyperglycemic Effects of Water-Soluble Fraction of Brazilian Propolis and Its Bioactive Constituent, 3,4,5-Tri-O-caffeoylquinic Acid
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作者：Toshiro Matsui ; Sumi Ebuchi ; Tomoko Fujise 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：11
页码：1797-1803
DOI：10.1248/bpb.27.1797
出版社：The Pharmaceutical Society of Japan
摘要：To clarify the suppression of postprandial blood glucose rise via α-glucosidase (AGH) inhibitory action by natural compounds, propolis was examined in this study. A single oral administration of propolis extract (50% methanol fraction on XAD-2 column chromatography) in Sprague–Dawley rats demonstrated a potent antihyperglycemic effect with the significant AUC _{0—120 min} reduction of 38% at a dose of 20 mg/kg compared to that of controls. Among the active compounds isolated from the fraction, 3,4,5-tri-caffeoylquinic acid was found to be a prominent candidate that exerts the effect and shows a strong maltase-specific inhibition with an IC₅₀ value of 24 μ M . In addition, the noncompetitive inhibition power apparently increased with the number of caffeoyl groups bound to quinic acid.
关键词：α-glucosidase;caffeoylquinic acid;propolis;antihyperglycemic effect;diabetes