文章基本信息

标题：Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents
本地全文：下载
作者：Hideaki Matsuda ; Yoshiko Kawaguchi ; Miho Yamazaki 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：10
页码：1611-1616
DOI：10.1248/bpb.27.1611
出版社：The Pharmaceutical Society of Japan
摘要：A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells. Activity-guided fractionation of the methanolic extract led to the isolation of two known lignans, (−)-cubebin (1) and (−)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), together with a new lignan, (−)-3-desmethoxycubebinin (3). Among these lignans, 1 and 2 showed a significant stimulatory activity of melanogenesis without any significant effects on cell proliferation.
关键词：Piper nigrum;cubebin;3,4-dimethoxy-3,4-desmethylenedioxycubebin;3-desmethoxycubebinin;murine B16 melanoma cell;stimulatory effect on melanogenesis