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标题：Effects of Ellagic Acid and 2-(2,3,6-Trihydroxy-4-carboxyphenyl)ellagic Acid on Sorbitol Accumulation in Vitro and in Vivo
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作者：Hidenori Ueda ; Kazuko Kawanishi ; Masataka Moriyasu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：10
页码：1584-1587
DOI：10.1248/bpb.27.1584
出版社：The Pharmaceutical Society of Japan
摘要：Caesalpinia ferrea M ART . (Leguminosae) called as Jucá is one of the medicinal plants in Brazil used for diabetes. From the fruits of this plant, ellagic acid (EA) and 2-(2,3,6-trihydroxy-4-carboxyphenyl)ellagic acid (TEA) have been recently isolated as aldose reductase (AR) inhibitors. In this study, we examined to prove the inhibitory activity against AR of EA and TEA in vitro , and EA in vivo by measurement of the accumulation of sorbitol, which is the product of glucose reduction catalyzed by AR. TEA was not examined in vivo because of its shortage of yield from the fruits. EA and TEA significantly and dose-dependently inhibited sorbitol accumulation in erythrocytes, lens and sciatic nerve under incubating with glucose in vitro . EA at a dose of 75 mg/kg/d showed the most potent inhibition of sorbitol accumulation in erythrocytes, lens and sciatic nerve at 50, 75 and 100 mg/kg/d in vivo . These results suggest that the inhibitory activity of EA against AR causes to inhibit sorbitol accumulation by in vitro and in vivo experiments. EA is distributed in fruits and vegetables, so that taking them might be able to relieve diabetic complications.
关键词：aldose reductase inhibitor;sorbitol accumulation;ellagic acid;2-(2,3,6-trihydroxy-4-carboxyphenyl)ellagic acid;diabetes;Caesalpinia ferrea