文章基本信息

标题：Trypanocidal Constituents in Plants 3. Leaves of Garcinia intermedia and Heartwood of Calophyllum brasiliense
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作者：Fumiko Abe ; Shinya Nagafuji ; Hikaru Okabe 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：1
页码：141-143
DOI：10.1248/bpb.27.141
出版社：The Pharmaceutical Society of Japan
摘要：The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi , the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A and the xanthone 8-desoxygartanin were isolated along with the biflavonoids podocarpusflavone A and amentoflavone, and friedelin from the former. Three xanthones, jacareubin, 6-deoxyjacareubin, and 1,3,5,6-tetrahydroxy-2-(3-methyl-2-butenyl)xanthone from the latter showed activity. The trypanocidal activity of these compounds against trypomastigotes, an infectious form of T. cruzi , was examined as well as gossypol, berberine chloride, and harmine for comparison.
关键词：Trypanosoma cruzi;Garcinia intermedia;Calophyllum brasiliense;trypanocidal activity;Chagas' disease;Guttiferae