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标题：Effects of Benzyl Glucoside and Chlorogenic Acid from Prunus mume on Adrenocorticotropic Hormone (ACTH) and Catecholamine Levels in Plasma of Experimental Menopausal Model Rats
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作者：Hiroji Ina ; Kenji Yamada ; Kosai Matsumoto 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：1
页码：136-137
DOI：10.1248/bpb.27.136
出版社：The Pharmaceutical Society of Japan
摘要：To investigate the effectiveness of benzyl β- D -glucopyranoside (BG) and chlorogenic acid (CA), the constituents of the fruit of Prunus mume , for relieving tension in experimental menopausal model rats (M-rats) caused by ether stress, the effects of BG and CA on adrenocorticotropic hormone (ACTH) and catecholamine (adrenaline, noradrenaline, and dopamine) levels were examined in the plasma of M-rats. Caffeic acid, quinic acid, and rosmarinic acid, which are compounds structurally related to CA, were also examined. BG obviously recovered catecholamine levels decreased by ether stress and increased dopamine to high levels. On the other hand, CA significantly decreased the ACTH level increased by ether stress and showed the greatest effect of all compounds. These results suggest that BG and CA may contribute to relieving the tension in M-rats caused by ether stress.
关键词：adrenocorticotropic hormone (ACTH) level;catecholamine level;Prunus mume;chlorogenic acid;benzyl β- D -glucopyranoside;ether stress