文章基本信息

标题：Drug–Drug Interactions between Antiarrhythmic Drugs in Chick Embryos
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作者：Yuji Yoshiyama ; Takashi Sugiyama ; Motoko Kanke 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：1
页码：128-130
DOI：10.1248/bpb.27.128
出版社：The Pharmaceutical Society of Japan
摘要：The drug–drug interactions between antiarrhythmic drugs were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. Procainamide or flecainide with and without propranolol was injected into the air sac of a fertilized egg. Electrocardiograms (ECGs) were recorded 0 to 60 min after the injection. After each drug injection alone, the heart rate was not different compared with the control. However, the heart rate was significantly decreased by combinations of procainamide and propranolol or flecainide and propranolol. In addition, arrhythmia was produced in combination with propranolol. These findings indicate that the drug–drug interactions between antiarrhythmic drugs have a marked influence on the heart rate in chick embryos.
关键词：drug–drug interaction;procainamide;flecainide;propranolol;chick embryo;electrocardiogram