文章基本信息

标题：Inhibitory Effects of Long-Term Administration of Ferulic Acid on Microglial Activation Induced by Intracerebroventricular Injection of β-Amyloid Peptide (1—42) in Mice
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作者：Hee-Sung Kim ; Jae-young Cho ; Do-Hoon Kim 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2004
卷号：27
期号：1
页码：120-121
DOI：10.1248/bpb.27.120
出版社：The Pharmaceutical Society of Japan
摘要：Flavonoids and monophenolic compounds have been well described in recent years as antioxidants and scavengers of reactive oxygen and nitrogen species. In the present study, we aimed to characterize the effects of long-term administration of ferulic acid on the centrally administered β-amyloid peptide (Aβ)^1—42-induced activation of microglial cells in mice. Aβ^1—42 increased the immunoreactivity of OX-42, a microglial marker, and interferon-γ in the hippocampus at 8 h after the intracerebroventricular injection. The effects were suppressed by long-term (4-week) pretreatment with ferulic acid. This inhibition of microglial cell activation may underlie the beneficial effects of long-term administration of ferulic acid on Aβ^1—42-induced toxicity in vivo .
关键词：β-amyloid peptide (Aβ);microglia;endothelial nitric oxide synthase;ferulic acid;Alzheimer's disease