文章基本信息

标题：Adenine, an Inhibitor of Platelet Aggregation, from the Leaves of Cassia alata
本地全文：下载
作者：Hiroyoshi Moriyama ; Toru Iizuka ; Masahiro Nagai 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：9
页码：1361-1364
DOI：10.1248/bpb.26.1361
出版社：The Pharmaceutical Society of Japan
摘要：Adenine was isolated as a platelet aggregating inhibitor from the leaves of Cassia alata by HPLC using a triacontylsilyl silica (C₃₀) column. The inhibitory effects of adenine and adenosine (positive control) on the platelet aggregation induced by collagen or adenosine 5′-diphosphate (ADP) as an aggregating agent was evaluated with a platelet aggregometer using a laser-scattering method. As a result, the inhibitory effect of adenine was observed in the platelet aggregation induced by collagen (1.0 μg/ml as the final concentration), but little inhibitory effect was noted in the aggregation induced by ADP (5.0 μ M as the final concentration), whereas adenosine exhibited potent inhibitory effects on platelet aggregation induced both by collagen and ADP under the same experimental conditions.
关键词：adenine;Cassia alata;platelet aggregation inhibitor;collagen