文章基本信息

标题：Ichthyotoxic and Anticarcinogenic Effects of Triterpenoids from Sandoricum koetjape Bark
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作者：Intan Safinar Ismail ; Hideyuki Ito ; Teruo Mukainaka 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：9
页码：1351-1353
DOI：10.1248/bpb.26.1351
出版社：The Pharmaceutical Society of Japan
摘要：After bioassay-guided fractionation of the extract from Sandoricum koetjape bark, which exhibited significant toxicity to killifish ( Oryzias latipes ), two ichthyotoxic triterpenoids were isolated and characterized as koetjapic acid and 3-oxo-olean-12-en-29-oic acid. These constituents, along with non-toxic katonic acid, had a remarkable inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O -tetradecanoylphorbol 13-acetate (TPA), which is a preliminary in vitro screening method for possible anti-tumor-promoting agents. Of the triterpenoids active in vitro , koetjapic acid appears to be a promising cancer chemopreventive agent, since it significantly delayed tumor promotion in two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz( a )anthracene and promoted by TPA.
关键词：ichthyotoxic activity;Epstein-Barr virus early antigen (EBV-EA);koetjapic acid;Sandoricum koetjape;cancer chemoprevention