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标题：Hypotensive Effect of Butein via the Inhibition of Angiotensin Converting Enzyme
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作者：Dae Gill Kang ; Yun Cheol Kim ; Eun Jin Sohn 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：9
页码：1345-1347
DOI：10.1248/bpb.26.1345
出版社：The Pharmaceutical Society of Japan
摘要：Butein (3,4,2′,4′-tetrahydroxychalcone), a plant polyphenol, has been known to elucidate endothelium-dependent vasodilation. In the present study, the hypotensive effect of butein and its possible mechanism, especially an angiotensin converting enzyme (ACE) inhibitory effect, were investigated. Intravenous injection of butein lowered the arterial blood pressure of anesthetized rats in a dose-dependent manner. The plasma ACE activities were significantly inhibited by the addition of butein in a dose-dependent manner, the IC₅₀ value of which was 198 μg/ml (730 μ M ). Moreover, angiotensin I-induced contraction was markedly attenuated by prior exposure of endothelium-intact aortic rings to butein, but angiotensin II-induced contraction was not altered. These results suggest that butein has a hypotensive effect, at least in part, via the inhibition of angiotensin converting enzyme.
关键词：butein;angiotensin converting enzyme (ACE);blood pressure