文章基本信息

标题：Cytotoxic Activity of Steroidal Glycosides from Solanum Plants
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作者：Tsuyoshi Ikeda ; Hidetsugu Tsumagari ; Takehiko Honbu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：8
页码：1198-1201
DOI：10.1248/bpb.26.1198
出版社：The Pharmaceutical Society of Japan
摘要：Since some Solanum -genera plants have traditionally been used as anti-cancer and anti-herpes agents from olden times, we examined the cytotoxic activity of typical steroidal glycosides with the framework of spirostane, furostane, spirosolane, and pregnane obtained from Solanum plants. Among these steroidal glycosides, the spirostanol glycosides having a β-lycotetraosyl moiety were the most effective against PC-12 and HCT-116 cell lines. The potency of activity was observed to be decreased in the order of spirostane, furostane, spirosolane, and pregnane type steroid glycosides. It was also suggested that the activity depend on the kind of oligosaccharide moiety and aglycone moiety.
关键词：Solanum-genera;cytotoxic activity;steroidal glycoside