文章基本信息

标题：Cholecystokinin Inhibits Food Intake Independent of Interleukin-1β Expression in the Brain
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作者：Libin Zhan ; Toru Hosoi ; Yasunobu Okuma 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：8
页码：1181-1183
DOI：10.1248/bpb.26.1181
出版社：The Pharmaceutical Society of Japan
摘要：Increasing evidence has suggested that cholecystokinin (CCK) is involved in immune-to-brain communication. The afferent vagus nerve is an important component for transmitting peripheral immune signals to the brain, such as those determining interleukin (IL)-1β expression in the brain and anorexia. In the present study, we investigated whether the anorexic effect of CCK, which also activates the afferent vagus nerve, is mediated via IL-1β expression in the brain. CCK-8 dose-dependently (8—320 μg/kg, i.p.) inhibited food intake in mice. However, IL-1β transcripts in the hypothalamus, the hippocampus and the brainstem were not significantly increased after the administration of CCK-8, even at the larger dose of 320 μg/kg. These findings suggest that the CCK-induced inhibition of food intake may be independent of IL-1β production in the brain, and indicate the diverse role of CCK in the regulation of the neuro-immune interaction.
关键词：cholecystokinin;interleukin (IL)-1β;food intake;afferent vagus nerve;immune-to-brain communication;inflammation