文章基本信息

标题：Effects on M5076-Hepatic Metastasis of Retinoic Acid and N-(4-Hydroxyphenyl) Retinamide, Fenretinide Entrapped in SG-Liposomes
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作者：Noriko Takahashi ; Kayoko Tamagawa ; Kazuyuki Shimizu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：7
页码：1060-1063
DOI：10.1248/bpb.26.1060
出版社：The Pharmaceutical Society of Japan
摘要：Retinoic acid (RA), a potent inducer of cell differentiation, and N -(4-hydroxyphenyl)retinamide (4-HPR, fenretinide), a potent inducer of apoptosis, are well known as anticancer agents that are administered orally to patients for leukemia, breast and prostate cancer, respectively. However, it has not been studied whether both retinoids are effective on metastatic cancer. In mice implanted with M5076 cells, murine reticulum cell sarcoma survival times were prolonged by i.v. treatment of RA and 4-HPR entrapped in liposomes containing soybean-derived sterylglucoside mixture (SG), which accumulates in liver. In contrast, free RA and 4-HPR were inactive. These results indicate that RA and 4-HPR in SG-liposomes exhibit anticancer efficacy on metastatic cancers, and may have great potential for clinical use in the treatment of various cancers.
关键词：retinoic acid;fenretinide;anticancer;M5076;liver metastasis;liposome