文章基本信息

标题：Cell Growth Inhibitory Effect of Cinnamic Acid Derivatives from Propolis on Human Tumor Cell Lines
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作者：Yukihiro Akao ; Hiroe Maruyama ; Kenji Matsumoto 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：7
页码：1057-1059
DOI：10.1248/bpb.26.1057
出版社：The Pharmaceutical Society of Japan
摘要：A cell growth inhibitory effect of drupanin and baccharin, ingredients of propolis, was found in human cancer cell lines. These compounds induced apoptosis in the cells characterized by morphological and nucleosomal DNA fragmentation analysis. Their effects were less potent compared with that of artepillin C, which is a known anticancer compound from propolis. Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin.
关键词：propolis;drupanin;cell growth inhibition;apoptosis;human tumor cell