首页    期刊浏览 2024年11月29日 星期五
登录注册

文章基本信息

  • 标题:Anti-complement Activity of Constituents from the Stem-Bark of Juglans mandshurica
  • 本地全文:下载
  • 作者:Byung-Sun Min ; Sun-Young Lee ; Jung-Hee Kim
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2003
  • 卷号:26
  • 期号:7
  • 页码:1042-1044
  • DOI:10.1248/bpb.26.1042
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Four known flavonoids and two galloyl glucoses isolated from the stem-bark of Juglans mandshurica (Juglandaceae), namely taxifolin (1), afzelin (2), quercitrin (3), myricitrin (4), 1,2,6-trigalloylglucose (5), and 1,2,3,6-tetragalloylglucose (6), were evaluated for their anti-complement activity against complement system. Afzelin (2) and quercitrin (3) showed inhibitory activity against complement system with 50% inhibitory concentrations (IC50) values of 258 and 440 μ M . 1,2,6-Trigalloylglucose (5) and 1,2,3,6-tetragalloylglucose (6) exhibited anti-complement activity with IC50 values of 136 and 34 μ M . In terms of the evaluation of the structure–activity relationship of 3,5,7-trihydroxyflavone, compounds 2, 3, and 4 were hydrolyzed with naringinase to give kaempferol (2a), quercetin (3a), and myricetin (4a) as their aglycones, and these were also tested for their anti-complement activity. Of the three aglycones, kaempferol (2a) exhibited weak anti-complement activity with an IC50 value of 730 μ M , while quercetin (3a) and myricetin (4a) were inactive in this assay system. Among the compounds tested, 1,2,3,6-tetragalloylglucose (6) showed the most potent anticomplement activity (IC50, 34 μ M ).
  • 关键词:Juglans mandshurica;anti-complement activity;1,2,3,6-tetragalloylglucose;1,2,6-trigalloylglucose;3,5,7-trihydroxyflavone
国家哲学社会科学文献中心版权所有