文章基本信息

标题：Melanin Biosynthesis Inhibitors from the Bark of Machilus thunbergii
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作者：Gao Li ; Hye Kyung Ju ; Hyuen Wook Chang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：7
页码：1039-1041
DOI：10.1248/bpb.26.1039
出版社：The Pharmaceutical Society of Japan
摘要：The bioassay-guided fractionation of the methylene chloride soluble portion of a methanol extract of Machilus thunbergii bark led to the isolation of four known lignans, machilin A (1), meso -monomethyl dihydroguaiaretic acid (2), nectandrin A (3) and nectandrin B (4), which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells (IC₅₀: 39.9, 15.1, 19.4 and 37.8 μ M , respectively).
关键词：Machilus thunbergii;Lauraceae;bark;lignan;melanin biosynthesis inhibitor