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标题：Antipruritic Effects of the Fruits of Chaenomeles sinensis
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作者：Hisae Oku ; Yoshimi Ueda ; Kyoko Ishiguro 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：7
页码：1031-1034
DOI：10.1248/bpb.26.1031
出版社：The Pharmaceutical Society of Japan
摘要：A 35% EtOH extract of the fruits of Chaenomeles sinensis , long utilized as a folk medicine for cough, significantly inhibited the pruritogenic agent compound 48/80 (COM)-induced scratching behavior in mice. Antipruritic activity-guided fractionation and purification yielded active quercetin, apigenin, and catechin derivatives, which exhibited significant inhibitory effects on COM-induced scratching behavior. To the best of our knowledge, apigenin (5), apigenin 7-glucronide (6), and apigenin 4′-methoxy-7-glucronide (acacetin 7-glucronide) (7) were isolated from the fruits of C. sinensis for the first time. The active fraction and these compounds also inhibited serotonin-, platelet activating factor-, and prostaglandin E₂-induced scratching behavior, but did not inhibit histamine-induced scratching behavior or locomotive behavior. This study also showed that the fruits of C. sinensis could be used to treat allergic itching sensation.
关键词：antipruritus;Chaenomeles sinensis;apigenin;quercetin;catechin;antiallergy