文章基本信息

标题：Inhibition of Experimental Allergic Rhinitis by the n-Butanol Fraction from the Anomalous Fruits of Gleditsia sinensis
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作者：Lin-Jun Fu ; Yue Dai ; Zheng-Tao Wang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：7
页码：974-977
DOI：10.1248/bpb.26.974
出版社：The Pharmaceutical Society of Japan
摘要：This study was conducted to clarify the effect of the n -butanol fraction from the anomalous fruits of Gleditsia sinensis L AM . (NBGS) on experimental allergic rhinitis. NBGS (100, 200, 400 mg/kg, p.o. ) dose-dependently inhibited nasal symptoms (sneezing and nasal rubbing) and dye leakage induced by antigen challenge into the nasal cavity of actively sensitized rats. Significant effects were observed at doses of 200 and 400 mg/kg. NBGS (200, 400 mg/kg) also showed a clear inhibition of sneezing and an inhibitory tendency on nasal rubbing induced by histamine in normal rats. At 400 mg/kg, it significantly reduced dye leakage induced by histamine into the nasal cavity of rats. Terfenadine (10 mg/kg, p.o. ), an antihistaminic drug, clearly inhibited the nasal symptoms and the amount of dye leakage induced by antigen or histamine. Furthermore, NBGS significantly reduced in vitro histamine release from rat peritoneal mast cells triggered by compound 48/80 at concentrations of 30 and 100 μg/ml. These results suggest that NBGS may be clinically effective in alleviating the nasal symptoms of allergic rhinitis, probably by inhibiting both histamine release from mast cells and nasal vascular permeability.
关键词：Gleditsia sinensis;allergic rhinitis;nasal symptom;histamine release;nasal vascular permeability