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标题：Effect of Radix Ginseng and Radix Trichosanthis on the Melanogenesis
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作者：Sook-Jung Im ; Kwen-Nam Kim ; Young-Gab Yun 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：6
页码：849-853
DOI：10.1248/bpb.26.849
出版社：The Pharmaceutical Society of Japan
摘要：Melanogenesis is a well known physiological response of human skin exposed to ultraviolet light, genetic reasons and other sources. In this study, we conducted to evaluate the effects of Radix Ginseng (RG) and Radix Trichosanthis (RT) on the melanogenesis in the B16 melanoma cells. The cells were treated for 48 h with RT at concentrations ranging from 1 to 50 μg/ml, RG at concentration of 10—1000 μg/ml, or RG at various doses (10—1000 μg/ml) with 25 μg/ml RT. Treatment with RT alone dose-dependently suppressed tyrosinase activity and melanin content compared with untreated control, and significantly inhibited cell proliferation. However, RG at various concentrations did not exhibit any significant change of them. Treatment with RT in the presence of various concentrations of RG suppressed tyrosinase activity and melanin content, similar to treatment with RT alone, but slightly increased cell proliferation. Furthermore, tyrosinase protein level was significantly decreased in treatment with 25 μg/ml RT alone and with a combination of 100 μg/ml RG. These results indicate that treatment with RG and RT significantly inhibits the melanogenesis in B16 cells, and raise the possibility that this combination may be effective in the whitening agent for the skin.
关键词：Radix Ginseng;Radix Trichosanthis;tyrosinase activity;melanogenesis