文章基本信息

标题：Oral Administration of Proteoglycan Isolated from Phellinus linteus in the Prevention and Treatment of Collagen-Induced Arthritis in Mice
本地全文：下载
作者：Gi-Young Kim ; Seung-Hoon Kim ; Sue-Yun Hwang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：6
页码：823-831
DOI：10.1248/bpb.26.823
出版社：The Pharmaceutical Society of Japan
摘要：To examine whether oral administration of proteoglycan derived from Phellinus linteus , which is known as the medicinal mushroom, can prevent or treat collagen-induced arthritis (CIA) in mice as experimental model of autoimmune disease. CIA was induced by intradermal injection of type II collagen (CII) emulsified with complete freund's adjuvant (CFA) into the base of the tail (on day 7) followed by a booster injection on day 21 into the footfad. To examine the ability of proteoglycan to effect the inhibition of CIA, doses of proteoglycan were orally administered on day 0 (pre-administration) or day 28 (post-administration) at two groups. The inhibition of CIA by oral administration of proteoglycan was associated with decrease in anti-CII IgG and IgG2a antibodies (Abs) as well as varying kinds of cytokines including IL-12, TNF-α, and IFN-γ. The results showed that administration of proteoglycan was followed by decrease of CIA of the mice in pre- and post-administration groups. Our findings suggest that immunomodulating proteoglycan isolated from P. linteus may be crucially involved in the prevention and treatment of autoimmune joint inflammation such as rheumatoid arthritis, although no definite role of anti-CII Abs in the human disease has been established.
关键词：RA;CIA;Phellinus linteus;proteoglycan;Th cell