文章基本信息

标题：Microbial Viability in Preparations Packaged for Single Use
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作者：Akiko Obayashi ; Shigeharu Oie ; Akira Kamiya 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：5
页码：667-670
DOI：10.1248/bpb.26.667
出版社：The Pharmaceutical Society of Japan
摘要：We evaluated microbial viability in preparations packaged for single use only which mandate that residual solution be discarded such as albumin and globulin preparations as blood products, preparations containing albumin (such as urokinase and interferon), fat emulsions, and a preparation containing fat emulsions (propofol). In most preparations, Serratia marcescens and Burkholderia cepacia proliferated rapidly at 30 °C. However, in globulin preparations containing 1—2.25% glycine to prevent protein degradation (Gamma-Venin P, Venilon-I, Globulin Injection, and Ahlbulin), no growth of S. marcescens and B. cepacia was detected over 24 h at 30 °C. For globulin preparations containing 1—2.25% glycine, the injunction to “Discard residual solution after the package has been used” in the package inserts can be revised to “It is possible to use residual solution within 24 h after the package has been used with storage in a cool place.”
关键词：globulin;albumin;interferon;propofol;glycine;microbial contamination