文章基本信息

标题：Inhibitory Effect of Oolong Tea on the Oxidative State of Low Density Lipoprotein (LDL)
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作者：Hiroshi Kurihara ; Harukazu Fukami ; Yoshiko Toyoda 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：5
页码：739-742
DOI：10.1248/bpb.26.739
出版社：The Pharmaceutical Society of Japan
摘要：In the present study, we investigated the anti-oxidant activity of oolong tea in an oxidation model using human low-density lipoprotein (LDL). Oolong tea suppressed the oxidation of LDL induced by 2-2′-azobis 4-methoxy-2,4-dimethyvaleronitrile (V70) in a dose-dependent manner, that is, it prolonged the lag time to 114.3%, 138% and 199.9% as compared with the control group at 0.5 μg/ml, 1.0 μg/ml, and 2.5 μg/ml, respectively. We also determined the scavenging effect of oolong tea on active oxygen radicals using the electron spin resonance (ESR) technique with 5,5-dimethyl-1-pyrroline N -oxide (DMPO) as a spin trapping agent. The intensity of the ESR signals for the DMPO–OOH adduct formed by the hypoxanthine/xanthine oxidase reaction system with DMPO decreased in the presence of oolong tea. The IC₅₀ of oolong tea was 19.9 μg/ml. These findings suggested that oolong tea has beneficial effects on health related to its anti-oxidative action.
关键词：oolong tea;antioxidant;low density lipoprotein (LDL);lag time;electron spin resonance (ESR)