文章基本信息

标题：Cytoprotective and Cytotoxic Effects of Curcumin: Dual Action on H2O2-Induced Oxidative Cell Damage in NG108-15 Cells
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作者：Pramote Mahakunakorn ; Michihisa Tohda ; Yukihisa Murakami 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：5
页码：725-728
DOI：10.1248/bpb.26.725
出版社：The Pharmaceutical Society of Japan
摘要：The ability of curcumin, a natural antioxidant isolated from Curcuma longa , to inhibit hydrogen peroxide (H₂O₂)-induced cell damage in NG108-15 cells was examined. When added simultaneously with 500 μ M H₂O₂, curcumin (25—100 μ M ) effectively protected cells from oxidative damage. However, when the cells were pretreated with curcumin (25—100 μ M ) for 1.5 h before H₂O₂ exposure, curcumin was unable to inhibit H₂O₂-induced cell damage. Instead, it caused a significant concentration-dependent decrease in cell viability after H₂O₂ exposure. This dual action of curcumin suggests that pretreatment with curcumin by itself did not have any significant effect on the viability of the NG108-15 cells, but it sensitized them to oxidative damage induced by H₂O₂ under our experimental conditions. It appears that these events may not relate to the antioxidant and free radical scavenging activities of curcumin.
关键词：curcumin;NG108-15 cell;hydrogen peroxide;oxidative damage;FK506