文章基本信息

标题：Inhibition of NO Production by Highly-Oxygenated Diterpenes of Orthosiphon stamineus and Their Structure–Activity Relationship
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作者：Suresh Awale ; Yasuhiro Tezuka ; Arjun H. Banskota 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：4
页码：468-473
DOI：10.1248/bpb.26.468
出版社：The Pharmaceutical Society of Japan
摘要：Nitric oxide (NO) has been implemented in various pathological processes. In the present study, 47 highly-oxygenated isopimarane-type and novel carbon framework staminane-type diterpenes isolated from Orthosiphon stamineus of Indonesia, Okinawa, Myanmar and Vietnam were evaluated for their inhibitory activity in NO production by lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. All the isolated diterpenes showed concentration-dependent inhibition of NO production in LPS-activated macrophage-like J774.1 cells, and based on the results, their structure–activity relationshis were established.
关键词：nitric oxide (NO) inhibition;structure–activity relationship;diterpenes;isopimarane-type;staminane-type;Orthosiphon stamineus