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标题：Scropolioside-D2 and Harpagoside-B: Two New Iridoid Glycosides from Scrophularia deserti and Their Antidiabetic and Antiinflammatory Activity
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作者：Bahar Ahmed ; Adnan Jathlan Al-Rehaily ; Tawfeq Abdullah Al-Howiriny 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：4
页码：462-467
DOI：10.1248/bpb.26.462
出版社：The Pharmaceutical Society of Japan
摘要：Five iridoid glycosides, including the two new compounds scropolioside-D₂ (1) and harpagoside-B (2), were isolated from the aerial parts of Scrophularia deserti D EL (Scrophulariaceae). Their structures were elucidated on the basis of spectral data to be 6- O -[2″,4″-di- O -acetyl-3″- O - trans -cinnamoyl)-α- L -rhamnopyranosyl]-8α-hydroxymethyl-1α,5β,6α,7α,9β-pentahydro-7(8)-epoxy-2-oxaind-3-ene-1- O -β- D -glucopyranoside-6′- O -acetate (1) and 5- O -β-hydroxy-8- O -β- trans -cinnamoyl-8α-methyl-1,6,7,9-tetrahydro-2-oxaind-3-ene-1- O -β- D -glucopyranoside (2), respectively. In addition, three more iridoid glycosides, scropolioside-D (3), koelzioside (4), and 8- O -acetyl-harpagide (5), were also isolated and characterized from this source. The biological activity and the structure activity relationship of the compounds were also studied, and scropolioside-D (3) and harpagoside-B (2) were found to possess significant antidiabetic and antiinflammatory activity, respectively.
关键词：Scrophularia deserti;scropolioside-D2;harpagoside-B;iridoid glycoside;antidiabetic activity;antiinflammatory activity