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标题：Quercetin Attenuates Oxygen–Glucose Deprivation- and Excitotoxin-Induced Neurotoxicity in Primary Cortical Cell Cultures
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作者：Hyun Joo Ha ; Yong Soo Kwon ; Shin Mi Park 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：4
页码：544-546
DOI：10.1248/bpb.26.544
出版社：The Pharmaceutical Society of Japan
摘要：The possible role of quercetin, a naturally occurring plant flavonoid, in protecting against oxygen–glucose deprivation (OGD)-, excitotoxins-, and free radical-induced neuronal injury in mouse cortical cell cultures was investigated. Pre- and co-treatment with quercetin (100 μ M ) inhibited 50 min OGD-, 20 μ M N -methyl- D -aspartate (NMDA)-, and 50 μ M kainate-induced neurotoxicity by 36, 22, and 61%, respectively. Quercetin significantly ameliorated free radical-induced neuronal injury caused by buthionine sulfoximine, sodium nitroprusside, ZnCl₂, and FeCl₂. These results suggest that quercetin may contribute a neuroprotective action against ischemic neural injury, partially via antioxidant actions.
关键词：quercetin;oxygen–glucose deprivation;N-methyl- D -aspartate;kainate;free radical;cortical culture