文章基本信息

标题：Hypolipemic Effect of Cyclocarya paliurus (Batal) Iljinskaja in Lipid-Loaded Mice
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作者：Hiroshi Kurihara ; Sumio Asami ; Hiroshi Shibata 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：3
页码：383-385
DOI：10.1248/bpb.26.383
出版社：The Pharmaceutical Society of Japan
摘要：We investigated the inhibitory effect of Cyclocarya paliurus (Batal.) Iljinskaja ( C. paliurus ) extract on postprandial hyperlipemia in mice. A single oral administration of C. paliurus extract (250 mg/kg) suppressed an increase in plasma triacylgycerol (TG) levels when fed with 5 ml/kg of lard and olive oil. The inhibition rates were 28.6% and 24.1%, respectively, but free fatty acid (FFA) levels in plasma were not significantly affected as compared with control group mice. In addition, C. paliurus extract showed inhibitory activity toward pancreatic lipase, a key enzyme of dietary TG absorption, with an IC₅₀ of 9.1 μg/ml in vitro . Our results suggested that the hypolipemic action of C. paliurus extract was probably interrelated with suppression of the activity of digestive lipase, and as a result, the blood lipid level was reduced.
关键词：Cyclocarya paliurus (Batal.) Iljinskaja (C. paliurus);triacylgycerol (TG);pancreatic lipase