文章基本信息

标题：Effect of Restraint and Footshock Stress and Norepinephrine Treatment on Gastric Emptying in Rats
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作者：Fumitake Tsukada ; Yoko Nagura ; Shinya Abe 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：3
页码：368-370
DOI：10.1248/bpb.26.368
出版社：The Pharmaceutical Society of Japan
摘要：We investigated the effects of restraint and footshock stress and norepinephrine treatment on gastric emptying. The gastric emptying was significantly inhibited by restraint stress. β₃-adrenergic antagonist canceled the inhibition of gastric emptying caused by restraint stress, while β₁-, β₂-, α₁-, and α₂-adrenergic antagonists did not affect the inhibition. Norepinephrine treatment also inhibited gastric emptying. The inhibition by norepinephrine treatment was canceled by β₁-, β₂-, and β₃-adrenergic antagonists, but not by α₁- and α₂-adrenergic antagonists. On the other hand, footshock stress did not affect gastric emptying. These results suggest that β₃-adrenoceptors play an important role in the inhibition of gastric emptying caused by restraint stress, while nonspecific β-adrenoceptors are involved in that caused by norepinephrine treatment.
关键词：restraint stress;footshock stress;norepinephrine;gastric emptying