文章基本信息

标题：The Ameliorating Effects of Acute and Chronic Administration of LiuWei Dihuang Wang on Learning Performance in Rodents
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作者：Ming-Tsuen Hsieh ; Sung-Jen Cheng ; Li-Wei Lin 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：2
页码：156-161
DOI：10.1248/bpb.26.156
出版社：The Pharmaceutical Society of Japan
摘要：The ameliorating effects of LiuWei Dihuang Wang (LDW) after single, one-week or two-week treatment of scopolamine (SCOP)-induced and p -chloroamphetamine (PCA)-induced amnesia by using the passive avoidance task and the facilitatory effects on two-way active avoidance performance in rats were studied. LDW (2 g/kg) after single treatment significantly prolonged the shortened step-through latency induced by SCOP and PCA. Then, SCOP- and PCA-induced amnesia was reversed by 1 and 0.1—1 g/kg LDW with one-week consecutive treatment respectively. For two-week consecutive treatment with LDW, the reversal from SCOP- and PCA-induced amnesia required only 0.01 g/kg. However, the rats treated with LDW only at 0.5, but not 0.01—0.1 g/kg, before or after each training session showed an increasing number of avoidances and a decreasing number of escapes on days 2—5 of learning. LDW at any dose alone did not influence the step-through latency in the training trial produced by non-shock rats, the motor activity and pentobarbital-induced hypnosis in rodents. These results suggest that LDW possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent on the learning models.
关键词：LiuWei Dihuang Wang;passive avoidance task;two-way active avoidance task