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标题：Antinociceptive and Antiinflammatory Effects of Niga-ichigoside F1 and 23-Hydroxytormentic Acid Obtained from Rubus coreanus
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作者：Jongwon Choi ; Kyung-Tae Lee ; Joohun Ha 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：10
页码：1436-1441
DOI：10.1248/bpb.26.1436
出版社：The Pharmaceutical Society of Japan
摘要：As an attempt to search for bioactive natural constituents exerting antinociceptive and antiinflammatory activities, we examined the potency of the extract of Rubus coreanus fruits by the activity-guided fractionation. The EtOAc- and BuOH fraction and those alkaline hydrolysates showed significant antinociceptive effects as assessed by writhing-, hot plate- and tail flicks tests in mice and rats as well as antiinflammatory effect in rats with carrageenan-induced edema. BuOH extract was subjected to column chromatography to obtain a large amount of niga-ichigoside F₁ (1,23-hydroxytormentic acid 28- O -glc), which was again hydrolyzed in NaOH solution to yield an aglycone 23-hydroxytormentic acid (1a). The aglycone, 23-hydroxytormentic acid, was much more potent in both antinociceptive and antiinflammatory tests than the glycoside, niga-ichigoside F₁. The antiinflammatory effects of these compounds were further supported by the reduction of carrageenan-induced lipid peroxidation and hydroxyl radical in serum. These results suggested that 23-hydroxytormentic acid might be an active moiety of niga-ichigoside F₁ present in R. coreanus .
关键词：Rubus coreanus;niga-ichigoside F1;23-hydroxytormentic acid;antinociceptive;antiinflammatory