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标题：Levels of some Acute-Phase Proteins in the Serum of Patients with Cancer during Radiotherapy
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作者：Mehmet Koc ; Seyithan Taysi ; Orhan Sezen 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：10
页码：1494-1497
DOI：10.1248/bpb.26.1494
出版社：The Pharmaceutical Society of Japan
摘要：The acute phase response involves changes in serum concentrations of a number of liver-synthesized proteins. Among these are C-reactive protein (CRP), ferritin (FER), transferrin (Trf) and ceruloplasmin (Cp). Determination of serum CRP, FER, Trf, and Cp was performed in 52 patients with inoperable head and neck cancer ( n =11), inoperable esophageal cancer ( n =10), rectal cancer ( n =9; operation was performed=5, inoperable=4), and lung cancer ( n =22), all of whom were treated with radical radiotherapy (RT). Post-radiotherapy CRP levels were significantly higher compared to the preradiotherapy levels ( p <0.001). We found decreased serum Trf levels during the irradiation period, while acute-phase proteins such as CRP, FER, and Cp levels increased during the RT period. Further studies on the roles of other acute phase reactants and the above mentioned parameters in a large-patients-with cancer group during radiotherapy are required to understand the role of markers, which are altered during radiotherapy.
关键词：radiotherapy;acute phase reactants;cancer