文章基本信息

标题：Influence of Histamine in a Liver Injury Model Induced by Propionibacterium acnes and Lipopolysaccharide
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作者：Hiroshi Kurihara ; Harukazu Fukami ; Sumio Asami 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2003
卷号：26
期号：10
页码：1393-1397
DOI：10.1248/bpb.26.1393
出版社：The Pharmaceutical Society of Japan
摘要：In normal mice, plasma histamine levels were 29.4±10.1 pmol/ml. When 0.1 μg of lipopolysaccharide (LPS) was intravenously injected into Propionibacterium acnes ( P. acnes )-primed ICR mice, histamine levels increased remarkably to 61.2±15.9 pmol/ml ( p <0.001). An increase was also observed in liver tissues. Oral administration of histidine at 200 mg/kg once daily for 5 d before intravenous LPS injection increased the plasma alanine aminotransferase (ALT) activity to 2936.5±356.3 IU/l, a significant change compared with the controls (2244.8±425.5 IU/l, p <0.05). The 24 h survival rate after LPS injection was 72.7% in the mice treated with 50 mg/kg of ranitidine, in contrast with 50% in the control group although the treatment did not significantly decrease the plasma ALT activity. On the other hand, 50 mg/kg of pyrilamine significantly reduced plasma ALT activity ( p <0.001). The results suggested that histamine levels are related to hepatic damage in the P. acnes plus LPS induction of liver injury.
关键词：Propionibacterium acnes;lipopolysaccharide (LPS);histamine